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It is currently being studied at doses ranging from 1 mg to 12 mg per week in clinical trials
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The landmark 2008 Metabolism RCT (N=116) comparing berberine 500 mg three times daily to metformin 500 mg three times daily found no statistically significant difference in HbA1c reduction after 3 months (both approximately 2.0 percentage points) [13]
10.1016/j.atherosclerosis.2012.05.007
Additionally, when succinyl-CoA is converted to succinate by succinate thiokinase, one molecule of GTP is generated, which can be readily converted to ATP by nucleoside-diphosphate kinase (NDPK)
Nevertheless, the discovery of product inhibition led to the development of potent inhibitors that block NS3 serine protease activity, NS protein processing, and HCV RNA replication
