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Patients can often maintain their weight loss with a lower dose after initial success, which can help balance effectiveness with tolerability. According to Lilly, both trials met their primary and all key secondary endpoints
GLOW and GLP-1 medications act through different receptor systems
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The endogenous intestinal GLP-1 sequence corresponded to a truncated form of GLP-1, formed by a monobasic cleavage between residues 77 and 78 in proglucagon, resulting in an amidated peptide with the full sequence of PG 78106 amide [29]
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doi: 10.1016/j.tifs.2023.06.013 350 MobiniRTremaroliVSthlmanMKarlssonFLevinMLjungbergMet al
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