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The first RCT to investigate the effect of liraglutide in patients with NAFLD was the LEAN study, in which 52 patients with NASH were randomized to either 48 weeks of treatment with liraglutide (1.8 mg/day) or placebo (66)

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To further uncover the effects of liraglutide on TGF-1 + IL-1-challenged fibroblasts, the gene expression profile of fibroblasts was investigated by RNA sequencing

They demonstrate that a murine model of diabetes is associated with the development of ER stress in beta cells

A cytoprotection-associated effect may be more visible under injury or stress conditions than in basal, unstressed cells

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