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During a one-year period of observation, the children were observed for signs of upper respiratory tract infections, lower respiratory tract infections, vitamin D toxicity, and deficiency
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For this reason, it was thought that the enzyme played an important role in ammonia detoxification, because since high [NH 4 + ] are toxic, this equilibrium position would be physiologically important
When vitamin C supply is sufficient, the HIF transcription factor is less active than in conditions of vitamin C deficiency
However, the sample size in that study was small, as only 16 rats (eight per group) were used in their experiment, and the study duration was short (11 days), which may have affected the statistical significance and generalizability of the results
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