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Some are clinically validated with thousands of patients in the evidence base
Oral NR (strongest human RCT base) Multiple RCTs (Martens 2018, Conze 2019, Dollerup 2018, Brakedal 2022) consistently raised blood NAD+ with favorable tolerability at doses up to 1,000 mg/day
One of the main benefits is detoxification, as glutathione helps to neutralize harmful toxins in the body and supports liver function
Others prefer evening so any initial side effects occur during rest
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