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Dietary fiber protects against diabetic nephropathy through short-chain fatty acid-mediated activation of G protein-coupled receptors GPR43 and GPR109A
and (2) forming hydrophobic ion pairs (HIP) with the peptide drug to enhance its membrane permeability
Hudson & Tabet 2003 Cochrane Review: A Cochrane Review of 15 clinical trials (including 13 of those in the meta-analysis above) assessed 1 to 3 g/day ALCAR supplementation versus placebo over 12 to 52 weeks in participants with mild to moderate dementia or cognitive decline
(99) demonstrated that aberrant gut microbiota accelerates renal failure progression through host metabolome alterations
Nature 541, 481487
