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BurgessECrakeRPhillipsEMorrinHRoydsJSlatterTet alIncreased ascorbate content of glioblastoma is associated with a suppressed hypoxic response and improved patient survival

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3 Ferroptosis and neurodegenerative diseases Iron is an essential trace element for maintaining brain function, playing vital roles in neuronal development, neurotransmitter synthesis, mitochondrial energy metabolism, myelin formation, and synaptic plasticity (Table 1), suggesting that therapeutic targeting of ferroptosis may offer a promising strategy for the prevention and treatment of NDDs