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The observed modulatory effects for kidney function tests are most likely attributable to the reinforcement of the endogenous antioxidant defense mechanisms and the attenuation of lipid peroxidation processes [75]

This animal model also exhibit a dysregulation of Nrf2-dependent antioxidant responses in the vasculature, which promotes the development of marked endothelial dysfunction and endothelial apoptosis in the presence of increased oxidative stress[281], mimicking the aging phenotype

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doi: 10.3390/ijms24032440 241 SakazakiFArakawaTShimizuROginoHOkunoTUenoH

This oxidative stress is a critical factor in the progression of diabetes

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