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Histopathological analysis using H&E staining revealed pronounced ballooning degeneration and cytoplasmic vacuolization in the APAP group, which were substantially alleviated by TA treatment (Figure 1D)

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NF1 is characterized by multiple benign neurofibromas, caf-au-lait spots, and an increased lifetime risk (approximately 813%) of developing MPNST (Evans et al., 2021)

Retatrutide demonstrated greater weight loss than survodutide in their respective Phase 2 trials (24.2% vs 18.7%), likely driven by its unique triple-agonist mechanism that adds GIP receptor activation