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Medicine and Science in Sports and Exercise
Key Takeaways Agonism Profile: Tirzepatide is a dual GLP-1/GIP agonist, while Retatrutide is a "triple agonist" targeting GLP-1, GIP, and Glucagon receptors
Sleep hygiene strategies: Consistent bedtime and wake time regulating circadian rhythm
PC=Placebo An RCT of nondiabetic patients (N = 1961)1: After 68 weeks, mean weight loss was 15% (15 kg) versus 2% (3 kg) PC
Appetite effects typically emerge around weeks 3-4
Skipping meals or not drinking enough water can also make hunger come back
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