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For chronic hives that do not respond to standard doses, a physician may add an H2 antihistamine (such as famotidine) or prescribe omalizumab (Xolair), a biologic injection with strong results in chronic spontaneous urticaria

doi: 10.1007/s12026-016-8841-7

Liepinsh E, Makrecka-Kuka M, Makarova E, Volska K, Svalbe B, Sevostjanovs E, et al

Sci Rep 13 (1), 7392

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