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Both reactions can be catalysed by protein disulphide isomerase (PDI) and possibly other oxidoreductases that share common domains with PDI (for a recent review, see Ellgaard & Ruddock, 2005)

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It has been studied for over 30 years across 100+ publications for its role in tissue repair, gut healing, and anti-inflammatory activity

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It tends to resolve as the body adapts, usually within the first few weeks to a month