Reduced methylation causes a reduction in the transfer of the sulphur from homocysteine into the sulphation cycle, leading to lower intracellular cysteine, and reduced production of glutathione
DOPAL reacts with -syn protein, leading to -syn accumulation, proteostasis disturbance and degeneration of dopaminergic neurons in PD models [69]
Treatment with GABA significantly restores neuron density compared to the model group, as evidenced by the large improvement and the ( p = 0.002), underscoring its neuroprotective effects
Potential targets include the central TGF- pathway, PDGF signaling, Rho/ROCK pathways involved in myofibroblast contraction, or focal adhesion kinase (FAK) signaling [86]
Steed DL
"Primary and secondary red ear syndrome: implications for treatment"