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What is measured in these rats and mice (and occasionally in small groups of human volunteers) is often not a hard endpoint like muscle strength or weight loss, but surrogate biomarkers: molecules in the blood that have an indirect link to a hard endpoint

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Incorrect and Impure Products: Many products contain the wrong amino acid sequence or have purity levels as low as 5-75%, filled with unknown chemical byproducts

Ligaments receive only about 10-20% of the blood flow that muscles do