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However, this remains speculative rather than evidence-based

At any rate, this cluster of adverse events was experienced by 22.9% of the 7.2mg group versus 6% of the 2.4mg group (it was not an adverse event at all in the original STEP 1 trial at all.) The researchers claim that Dysaesthesia adverse events were mild for most participants who experienced them: and that Most participants recovered from the event by the end of the trial. Of course we dont know if they will come back and for those who hadnt recovered, we dont know how this impacts their life/quality of life

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The initial elution was isocratic with 30% acetonitrile for 2 min, followed by a linear gradient for 15 min up to 100% acetonitrile

That means their fatty liver disease essentially resolved