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This generates an even greater accumulation of free radicals, mainly superoxide (O 2 ) and hydroxyl compounds (OH ) [41]

Sanders SP, Zweier JL, Harrison SJ, Trush MA, Rembish SJ, Liu MC: Spontaneous oxygen radical production at sites of antigen challenge in allergic subjects

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Once activated, these caspases cleave gasdermins to liberate the pore-forming N-terminal domains, enabling their targeting of cellular membranes to form large transmembrane pores, which disrupts cellular electrochemical gradient, and leads to water influx and cell swelling (160, 161)

We also summarize the common treatment strategies for UC, including lifestyle interventions, aminosalicylic acid preparations, corticosteroid drugs, biologics, fecal microbiota transplantation, and other drugs for symptomatic treatment

This work demonstrated that GLP-1RA treatment was associated with a significant 29% reduction in MALOs compared to non-use (IRR: 0.71, 95%CI: 0.57-0.88, P = 0.003) over a median follow-up of approximately 70,045 patient-years