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A major role of the mitochondrial malic enzymes, which includes the NAD(H)-dependent ME2 enzyme, is principally to provide the cell with an alternate source of pyruvate under conditions where glycolytic flux in reduced
To the support team's credit, the answer was direct, succinct, and complete
27(5):384389 Murea M, Freedman BI, Parks JS, Antinozzi PA, Elbein SC, Ma L (2010) Lipotoxicity in diabetic nephropathy: the potential role of fatty acid oxidation
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