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Compounded Two main pathways exist for prescription GLP-1 access: FDA-approved branded drugs (Ozempic, Wegovy, Mounjaro, Zepbound) dispensed by retail/mail-order pharmacies, and compounded semaglutide and tirzepatide from licensed 503A compounding pharmacies
While still in clinical trials, early data suggests gastrointestinal side effects, including nausea and burping, occur at rates comparable to or slightly higher than tirzepatide
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Laboratory studies using rodent models demonstrate activation of neurons within hindbrain structures such as the area postrema and nucleus tractus solitarius following amylin receptor stimulation [1]
Dose, duration, adherence, and changes in other medications over time are also important unanswered issues. Researchers say randomized clinical trials will be needed to confirm the findings and better understand how GLP-1 medications may affect cardiovascular risk in people with autoimmune diseases
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