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Switching should be clinician-led to avoid dose mismatch and unnecessary symptoms

*Correspondence: Xian-Feng Zhang, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Obesity, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Start slowly and increase the dosage if necessary

Common side effects like nausea, vomiting, and diarrhea remain, and long-term safety for brain protection needs more study

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