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Two estimands (treatment regimen estimand and efficacy estimand), based on the ICH E9(R1) guidance 32 , were used to assess treatment efficacy from different perspectives and accounted for intercurrent events differently
Chronic kidney disease (CKD) (e.g., FLOW), 3
It plays a vital role in generating energy in the body, regulating mood, and aiding in the healing and repair of damaged tissues
The clinical picture is nuanced: research suggests GLP-1 therapy may support cardiovascular health in some patients, but individual responses vary significantly based on genetics and overall health status
The participants followed a very low-energy ketogenic diet for 8 weeks
Although this can support weight loss goals, significant reductions in calorie intake can sometimes affect reproductive hormone production
