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When intact GLP-1(736)NH 2 (also termed active GLP-1) enters the capillaries of the small intestine, it is rapidly degraded N-terminally by the enzyme dipeptidyl peptidase-4 (DPP-4) to form the metabolite GLP-1(936)NH 2 , which is devoid of insulinotropic activity [4,5,6]
In SURMOUNT-1, the most common treatment-emergent adverse events were gastrointestinal: nausea (24.6-33.3% across doses vs 9.5% placebo), diarrhea (18.7-21.2%), vomiting (5.7-12.2%), and constipation (5.8-11.5%)
Epub 2024 Mar 17
Blood Sugar Control: Stimulates insulin release and reduces glucagon production, contributing to improved blood sugar control in individuals with type 2 diabetes
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