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This creates a vicious cycle: viral inflammation depletes antioxidants, genetic bottlenecks prevent the synthesis of new antioxidants, and the resulting oxidative stress causes the mitochondria to shut down ATP production, leading to the debilitating fatigue that characterizes ME/CFS and Long COVID

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The dose-dependent nature of semaglutide-associated nodules, documented in the first published case report, suggests that dose reduction may resolve the problem when nodules occur repeatedly

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Pro-apoptotic complexes of BAX and BAK on the outer mitochondrial membrane