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110 - 116 Copyright Copyright The Authors 2008 Over the last few years, increasing evidence has shown that hyperhomocysteinaemia is an independent risk factor for the development of CVD ( Reference Wyss and Schulze 1 , Reference Harbor-Gonalves, Vaz and Bezzi 2 ) and may be associated with neurodegenerative disease ( Reference Obeid and Herrmann 3 , Reference Bender, Koch and Elstner 4 ) , diabetes ( Reference Wijekoon, Brosnan and Brosnan 5 ) and end-stage renal dysfunction ( Reference Taes, Delanghe and De Vriese 6 , Reference Taes, Delanghe and De Bacquer 7 )

In seriously ill patients it may be advisable to administer both vitamin B12 and folic acid while awaiting the results of distinguishing laboratory studies

Common injection site reactions are characterized by itching and burning at the site of administration with or without thickening of the skin (welting)

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