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Indeed, GDH1 knockdown reduced while exogenous -KG supplementation elevated intracellular -KG abundance (Extended Data Fig

Safety profiles vary significantly : IV administration carries serious risks including anaphylaxis, hepatotoxicity, and potential endotoxin contamination, while oral supplements typically cause only mild gastrointestinal effects like flatulence or loose stools

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It works by reducing oxidative stress and influencing melanin production, which can affect skin tone and clarity

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