It can also decrease the cellular action of circulating thyroid hormones, potentially interfering with medications like Levothyroxine used for hypothyroidism, which could paradoxically worsen fatigue if unmonitored
Effects last several hours
Research suggests it activates AMPK
In a RCT comparing low- to intermediate-risk PCa patients treated with either surgery or RT (without ADT), the sexual function scores of the Expanded Prostate Index Composite (EPIC-26) were significantly higher for men receiving RT at two years post-treatment [306]
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NICE has not yet issued guidance on either agent, as appraisal processes are typically initiated only after regulatory approval, although scoping can occur earlier
