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In MASH patients/models, the expression/activity of several antioxidants generally decreases due to damage of hepatic and extrahepatic cells, which in turn worsens the damage

DOI:10.1007/s00125-012-2685-z [ Links ] 11

Nuclear factor-B The nuclear factor-B (NF-B) is an important inducible transcription factor playing a key role in processes of the immune and inflammatory responses, cellular adhesion, differentiation, proliferation, and apoptosis (Bonizzi and Karin 2004)

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As part of the erythrocyte antioxidant system, Prx2 is responsible for the removal of low H 2 O 2 concentrations, since the Trx system has a limited capacity for Prx2 regeneration into its reduced active form [32, 59, 60, 73]

Recovery can be frustrating, particularly when symptoms become recurrent or develop into longer-term tendon problems