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(Previously, Ozempic was being used for weight loss but had only been approved for diabetes.) In the years following approval, a growing number of household names from Oprah to Elon Musk spoke publicly about their positive experiences using GLP-1s for weight loss
Gibson JE, Hubbard RB, Smith CJ, Tata LJ, Britton JR, Fogarty AW
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In one study, participants regained two-thirds of their previous weight loss within the year after stopping the medication
A gradient shallow enough to resolve positional isomers, or peptide mapping after enzymatic digestion, speaks to this question
The 12mg group may have had different baseline compositions, or the additional weight loss at 12mg may have included a slightly higher proportion of lean tissue
