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That changed in 2025 with the publication of SURMOUNT-5, the first randomized head-to-head trial, published in the New England Journal of Medicine
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Generally, you should continue established IBS therapies including antispasmodics, fiber supplements, and probiotics unless side effects become problematic
Originally designed to help manage type 2 diabetes, GLP-1 receptor agonists have gained widespread attention for another reason: their ability to support significant, sustained weight loss
Combining adequate protein intake (1.2 to 1.6 g/kg daily), consistent resistance training, and targeted therapies like peptide therapy can protect your muscle while maximizing fat loss
doi: 10.1016/j.tem.2020.02.006 24 MinTBainSC
