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For serum-free media it is best to add L-glutamine along with GlutaMAX supplement

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MK-677 is a first-in-class ghrelin mimetic that increases both GH and IGF-1 levels without altering cortisol or testosterone, offering anabolic potential with minimal endocrine disruption. Murphy et al., Nature Reviews Drug Discovery How Does MK-677 Work

This is another reason why there have been few successful clinical trials globally

What they did: Isolated human chondrocytes (from osteoarthritis patients and healthy donors) were exposed to AOD-9604 at doses 1 to 1000 nM