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M1 macrophages enhance inducible nitric oxide synthase (NOS2 or iNOS) expression, thereby promoting NO production from L-arginine (79)

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The direct assessment of MDA and 4-HNE is not very sensitive, since the major portion of these reactive aldehydes is attached to proteins or other biomolecules and therefore before analysis, should be released, otherwise, they remain undetected (Esterbauer et al

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