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In reverse mode NET causes an efflux of the cytoplasmic pool of presynaptic norepinephrine into the synaptic cleft, where it can activate postsynaptic -1 and -1 receptors to elevate systemic vascular resistance and stimulate cardiac output (Vansal & Feller 1999

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The isolated pancreata were placed into 15 mL conical tubes containing 10 mL of 0.23 mg/mL liberase and incubated at 37 C for 30 min

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