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The production of GLP-1 receptor agonists has evolved significantly since their initial development for diabetes management
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El lanzamiento se da en un pas donde ms del 61% de los adultos vive con exceso de peso y donde, hasta ahora, los tratamientos de ltima generacin eran inaccesibles para la mayora por su elevado costo
Strategies that deplete GSH, such as using inhibitors like BSO which is inhibitor of -glutamylcysteine synthetase (-GCS) , the rate-limiting enzyme in glutathione (GSH) synthesis or by combining prodrug activation with GSH depletion in nanosystems, have shown promise in overcoming MDR and improving chemotherapy effectiveness [72]
For instance, altered gut motility can lead to prolonged intestinal transit time, potentially increasing the exposure of the gut mucosa to pathogens like Candida
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