When adverse effects occurred, they were typically mild and transient, with the most common being mild to moderate headaches (similar frequency to placebo groups), minor injection site reactions (redness, slight swelling), and gastrointestinal effects at higher oral doses (nausea, diarrhea)
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Safety Assessment Acute toxicity A single subcutaneous injection of AOD 9604 (50 mg/kg) did not cause death or obvious toxic reactions in mice
B12 injections are most appropriate for people with confirmed or suspected B12 deficiency
Studies of chondrocyte cultures suggest that it promotes proteoglycan and type II collagen synthesis, which has driven exploration of potential utility in joint and cartilage repair models