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172 Under normal conditions, protein synthesis prevails over the other cysteine-dependent pathways
People whose bodies do not generate enough intrinsic factor can become vitamin B12 deficient
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The MCSCF method revealed that the mixing of orbitalsthose occupied by electrons and those unoccupied [92]leads to a significant transfer of electron densities [93,94,95], and even electrons [96, 97], from biological substrates to vitamin B12 cofactors, as well as to the intermolecular orbitals formed between the cofactors and active substrates [93,94,95], aligning theoretical results with experimental observations [2, 90]
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By treating metabolically active adipocytes and hepatocytes with 5-amino-1-methylquinolinium, researchers can precisely inhibit intracellular NNMT activity, monitor changes in the nicotinamide pathway and NAD+ levels, and analyze effects on energy metabolism
