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At the same time, animal work shows potential benefits
Defective autophagic degradation promotes accumulation of intracellular autoantigens and enhances presentation of self-derived peptides, contributing to loss of self-tolerance
Phosphodiesterase-5 inhibitors such as sildenafil are generally safe to use alongside GLP-1 medications, though they are contraindicated with nitrates and should be used cautiously in certain cardiovascular conditions
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