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[11] [13] Metabolism refers to the complex biochemical processes by which the body converts food into energy, and basal metabolic rate (BMR) is the number of calories the body burns at rest to maintain vital functions

While the composite kidney outcome including a 50% sustained decrease in eGFR was not statistically significant (HR, 0.71

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However, this may only happen after starting the medication or increasing the dose

Oral dosing runs higher than injectable to compensate for reduced absorption