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While generally recognized as safe for the broader population, NAC does interact with several types of medications

Competing interests The authors declare that they have no competing interests

Statistical significance was assessed by ordinary One-Way ANOVA followed by Dunnetts multiple comparisons test in b , c , d

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Testing may provide analytical information about a submitted sample or batch, but it is not Health Canada authorization and does not establish clinical suitability

Key points Amyotrophic lateral sclerosis (ALS), with a lifetime risk of ~1/350, represents an area of huge unmet need and is a useful model of neurodegeneration, with measurable changes in motor function over a relatively short time frame