In humans, nearly all circulating GLP-1 is one of the latter two forms (89)
They also discuss why women using hormone therapy may experience better outcomes on GLP-1 medications, why estrogen is not simply a weight loss tool, and why menopause can be understood not only as a biological transition, but as a "body, mind, and soul" transformation
The twenty-eight day guideline provides safety margin
A full stomach on top of slowed gastric emptying is a bad combination
Symptoms vary: Both low and high IGF-1 can present subtly
This protective association has been repeatedly observed, linking GLP-1RA use to lower risks of POAG, ocular hypertension, and the need for first-line glaucoma treatment in large cohorts of T2DM patients [105,106,107]