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A systematic search was conducted across PubMed, Google Scholar, SCOPUS, MEDLINE, and EMBASE from inception to January 17, 2025, yielding over 1.3 million articles

Long-term human safety data does not yet exist

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Due to its classification and mechanism, peptide therapy is typically explored under the guidance of licensed healthcare practitioners

Interestingly, in trajectory 3 after 750 ns, the dynamic ECD moves back toward the TMD and is stabilized in a conformation that forms contacts mainly with ECL1, resembling the closed ECD conformation in the crystal structure

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