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30 : 555559 Janiri L, Falcone M, Persico A, Tempesta E

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Third, although existing studies consistently demonstrate beneficial effects on hepatic steatosis and inflammation, the lack of head-to-head mechanistic and biomarker-based comparisons restricts the ability to distinguish between different GLP-1RAs or combination therapies in terms of their molecular pathways, immunemetabolic regulatory efficiency, and predictive biomarkers of therapeutic response

Zhu et al

First, batch-to-batch variations in physicochemical properties such as particle size distribution and drug loading remain an ongoing issue