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Leucine-, arginine-, and methionine-derived SAM can bind their sensors during high intracellular concentrations, thereby disrupting the interaction of the sensors with GATOR1/2, relieving the inhibition of GATOR complex, and activating mTORC1
doi: 10.3389/fendo.2023.1215755 87 LiJChenQWangJHuangGYeH
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the product only needs to be obtained as the beta polymorph, it is appropriate to initiate crystallisation by seeding with beta crystals
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