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Here, we aim to investigate the interactions between the usage of semaglutide (e.g., Ozempic, GLP-1-RA), empagliflozin (e.g., Jardiance, SGLT-2i), and the gut microbiome
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By integrating network pharmacology, MR analysis, and transcriptomic validation, we demonstrate that metformins multimodal actions, spanning metabolic regulation, neuroinflammation, and antiviral defense, may underlie its stronger neuroprotective effects
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This dual action improves energy use and fat breakdown
GDF15 mediates the effect of skeletal muscle contraction on glucose-stimulated insulin secretion
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