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This combination is not FDA-approved, and no clinical trials have evaluated its safety or efficacy

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doi: 10.1002/(ISSN)1096-9136 28 KreymannBWilliamsGGhateiMABloomSR

GIP is another incretin hormone secreted after meals

The pivotal STEP 1 trial, published in The New England Journal of Medicine, described the same pattern in its 1,961 randomized adults: nausea and diarrhea were the most common adverse events with semaglutide, and they were "typically transient and mild-to-moderate in severity and subsided with time." Transient is not a promise for any individual, but it is what the aggregate data showed over 68 weeks