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decrease, weakening GPP-1 and GIP act as complementary hormones of the incretin effect, complementing each other in the regulation of insulin secretion, glucose, appetite, and lipid metabolism

The researchers also analyzed records to match the 15,000-plus GLP-1 users to a control group, matching the groups across age, race, ethnicity, body mass index, breast density and diabetes status and finding that those who had been prescribed GLP-1 drugs at Penn Medicine were 30.5% less likely to be diagnosed with breast cancer

The authors conclude that semaglutide affects weight loss primarily through fat mass reduction, but loss in lean mass leads to concerns, especially from larger clinical studies

Semaglutide enhances vascular health by improving blood flow and reducing arterial stiffness

Potential benefits of split dosing include reduced GI side effects (lower peak concentration), more consistent appetite suppression throughout the week, and better tolerance at higher doses