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When exposed to external factors such as elevated temperatures, chemical toxins, oxidants, and viral pathogens, these erythrocytes undergo significant morphological changes and exhibit apoptotic features

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Therefore, further investigation of the effect of TNF- on EBV reactivation and its specific mechanism is highly clinically important

They found that plasma S100A8/A9 levels were significantly elevated in severe sepsis patients and correlated with left ventricular systolic dysfunction and higher SOFA scores