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Free Radical Research, 2000

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Human trials show mild improvement in knee osteoarthritis symptoms

Significant disparities exist between mouse models and human conditions in terms of pathophysiology and treatment outcomes, as numerous clinical trials have shown that drugs effective in mouse models fail to offer clinical benefits in humans

Further well-designed, multicenter randomized controlled trials employing standardized and sensitive apnea detection methods are essential to definitively evaluate this potential application (45, 78)