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In 1902 they discovered in anaesthetised dogs that a chemical messenger secreted by the intestinal lining into the bloodstream helped to stimulate the pancreas to produce digestive juices whenever food or acid was introduced into the duodenum

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Both target overlapping hormonal pathways (GLP-1 and GIP), amplifying side effects like severe nausea, vomiting, or pancreatitis without enhancing weight loss

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