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doi:10.1016/j.pep.2011.05.012

IGF-1 availability is tightly regulated by the so-called insulin- like growth factor binding proteins (IGFBPs), which may act by increasing IGF-1 half-life, from minutes to hours (most commonly by forming a tertiary complex with Acid-Labile Subunit and IGFBP3), however blocking its binding to the insulin-like growth factor 1 receptor (IGF- 1R) [7]

Thus, patients with active malignancy should not be treated with tesamorelin

Complementary practices such as liming, gypsum, and biochar application, along with biofertilizers including plant growth-promoting rhizobacteria (PGPR) and mycorrhizal fungi, strengthen resilience to abiotic stress

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