What they found: In normal obese mice: AOD-9604 reduced body fat by 21 % vs placebo, hGH by 24 % The AOD-9604 effect was fully dependent on the 3-adrenergic receptor , in knock-out mice no effect The hGH effect was partly independent of 3-AR , in knock-out mice there was still ~10 % fat reduction AOD-9604 did not raise IGF-1 (control level), whereas hGH raised IGF-1 by 80 % No changes in growth, organ weights (except adipose tissue), fasting insulin Why it matters: The study provided the mechanistic basis for AOD-9604 and confirmed the key business hypothesis: it is possible to separate the lipolytic effect of GH from its growth effect
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Note the confluence of drugs working on the growth hormone axis in this Table and the one above
doi:10.1152/ajpendo.2000.279.3.E501 Ng FM, Sun J, Sharma L, Libinaka R, Jiang WJ, Gianello R
AOD9604 did not stimulate the production of IGF-1 in any of the systems studied, and elicits its fat-reducing effects without inducing insulin resistance a key pharmacological distinction from intact hGH that makes it a uniquely clean research tool for studying lipolytic mechanisms in isolation