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GT-activated prodrugs and potential nephrotoxicity Gamma-glutamyl transferase being the initial and limiting step in GT-activated prodrugs processing and because GT is highly expressed on the luminal surface of the proximal tubules in the kidney, potential nephrotoxicity could have been a limitation in the usage of this class of compound when administered systematically
This dual mechanism can lead to greater appetite suppression and more pronounced metabolic effects for some patients
Squire 1989
The serious side effects such as pancreatitis and kidney issues are rare across all options
Carthy, J
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